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COMMUNICATIONS
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4923-4926
4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells
John S. Wai,
Melissa S. Egbertson,
Linda S. Payne,
Thorsten E. Fisher,
Mark W. Embrey,
Lekhanh O. Tran,
Jeffrey Y. Melamed,
H. Marie Langford,
James P. Guare, Jr.,
Linghang Zhuang,
Vanessa E. Grey,
Joseph P. Vacca,
M. Katharine Holloway,
Adel M. Naylor-Olsen,
Daria J. Hazuda,
Peter J. Felock,
Abigail L. Wolfe,
Kara A. Stillmock,
William A. Schleif,
Lori J. Gabryelski, and
Steven D. Young
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4927-4929
Design and Synthesis of New Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase
Kazuyuki Ohmoto,
Tetsuya Yamamoto,
Toshihide Horiuchi,
Hirotoshi Imanishi,
Yoshihiko Odagaki,
Kazuhito Kawabata,
Tomohiko Sekioka,
Yasushi Hirota,
Shozo Matsuoka,
Hisao Nakai, and
Masaaki Toda
, John C. Cheronis
, Lyle W. Spruce
, Albert Gyorkos
, Maciej Wieczorek
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4930-4933
A Novel Class of Potent 3-Isoxazolol GABAA Antagonists: Design, Synthesis, and Pharmacology
Bente Fr lund,
Lena Tagmose,
Tommy Liljefors,
Tine Bryan Stensbl,
Christine Engblom,
Uffe Kristiansen, and
Povl Krogsgaard-Larsen
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ARTICLES
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4934-4947
Pyrazole Ligands: Structure-Affinity/Activity Relationships and Estrogen Receptor- -Selective Agonists
Shaun R. Stauffer,
Christopher J. Coletta,
Rosanna Tedesco,
Gisele Nishiguchi,
Kathryn Carlson,
Jun Sun,
Benita S. Katzenellenbogen, and
John A. Katzenellenbogen
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4948-4963
Development of New Hydroxamate Matrix Metalloproteinase Inhibitors Derived from Functionalized 4-Aminoprolines
Michael G. Natchus,
Roger G. Bookland,
Biswanath De,
Neil G. Almstead,
Stanislaw Pikul,
Michael J. Janusz,
Sandra A. Heitmeyer,
Erin B. Hookfin,
Lily C. Hsieh,
Martin E. Dowty,
Charles R. Dietsch,
Vikram S. Patel,
Susan M. Garver,
Fei Gu,
Matthew E. Pokross,
Glen E. Mieling,
Timothy R. Baker,
David J. Foltz,
Sean X. Peng,
David M. Bornes,
Michael J. Strojnowski, and
Yetunde O. Taiwo
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4964-4972
A Novel Series of 4-Piperidinopyridine and 4-Piperidinopyrimidine Inhibitors of 2,3-Oxidosqualene Cyclase-Lanosterol Synthase
George R. Brown,
David M. Hollinshead,
Elaine S. E. Stokes,
David Waterson,
David S. Clarke,
Alan J. Foubister,
Steven C. Glossop,
Fergus McTaggart,
Donald J. Mirrlees,
Graham J. Smith, and
Robin Wood
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4973-4980
Fluorosulfonyl-Substituted Xanthines as Selective Irreversible Antagonists for the A1-Adenosine Receptor
Anthony R. Beauglehole,
Stephen P. Baker, and
Peter J. Scammells
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4981-4992
Slow-Onset, Long-Duration 3-(3',4'-Dichlorophenyl)-1-indanamine Monoamine Reuptake Blockers as Potential Medications To Treat Cocaine Abuse
Mark Froimowitz,
Kuo-Ming Wu,
Adel Moussa,
Reem M. Haidar,
Jurjus Jurayj,
Clifford George, and
Eliot L. Gardner
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4993-4997
Highly Potent and Selective Inhibition of Varicella-Zoster Virus by Bicyclic Furopyrimidine Nucleosides Bearing an Aryl Side Chain
Christopher McGuigan,
Hubert Barucki,
Sally Blewett,
Antonella Carangio,
Jonathan T. Erichsen,
Graciela Andrei,
Robert Snoeck,
Erik De Clercq, and
Jan Balzarini
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4998-5002
D-Amino Acid Scan of  -Melanocyte-Stimulating Hormone: Importance of Trp8 on Human MC3 Receptor Selectivity
Paolo Grieco,
Preeti M. Balse,
David Weinberg,
Tanya MacNeil, and
Victor J. Hruby
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5003-5009
5-Azidoimidacloprid and an Acyclic Analogue as Candidate Photoaffinity Probes for Mammalian and Insect Nicotinic Acetylcholine Receptors
Shinzo Kagabu,
Peter Maienfisch,
Aiguo Zhang,
Joaquin Granda-Minones,
Joerg Haettenschwiler,
Hartmut Kayser,
Thomas Maetzke, and
John E. Casida
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5010-5016
Synthesis and Biological Activity of a Novel, Highly Potent Progesterone Receptor Antagonist
Ulrike Fuhrmann,
Holger Hess-Stumpp,
Arwed Cleve,
Günter Neef,
Wolfgang Schwede,
Jens Hoffmann,
Karl-Heinrich Fritzemeier, and
Kristof Chwalisz
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5017-5029
A Potent, Long-Acting, Orally Active (2R)-2-[(1R)-3,3-Difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: A Novel Muscarinic M3 Receptor Antagonist with High Selectivity for M3 over M2 Receptors
Morihiro Mitsuya,
Kensuke Kobayashi,
Kumiko Kawakami,
Atsushi Satoh,
Yoshio Ogino,
Taro Kakikawa,
Norikazu Ohtake,
Toshifumi Kimura,
Hiroyasu Hirose,
Akio Sato,
Tomosige Numazawa,
Takuro Hasegawa,
Kazuhito Noguchi, and
Toshiaki Mase
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5030-5036
Synthesis and in Vitro and in Vivo Activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-Alkenyl-, -N-Alkynyl-, and -N-Cyanoalkyl-5,9-dimethyl-2'-hydroxy-6,7-benzomorphan Homologues
Everette L. May,
Arthur E. Jacobson,
Mariena V. Mattson,
John R. Traynor,
James H. Woods,
Louis S. Harris,
Edward R. Bowman, and
Mario D. Aceto
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5037-5043
Optimization of Substituted N-3-Benzylimidazoquinazolinone Sulfonamides as Potent and Selective PDE5 Inhibitors
David P. Rotella,
Zhong Sun,
Yeheng Zhu,
John Krupinski,
Ronald Pongrac,
Laurie Seliger,
Diane Normandin, and
John E. Macor
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5044-5049
Synthesis and Evaluation of Isothiocyanate-Containing Derivatives of the  -Opioid Receptor Antagonist Tyr-Tic-Phe-Phe (TIPP) as Potential Affinity Labels for -Opioid Receptors
Dean Y. Maeda,
Fred Berman,
Thomas F. Murray, and
Jane V. Aldrich
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5050-5054
Extended TIP(P) Analogues as Precursors for Labeled -Opioid Receptor Ligands
Vivek Kumar,
Thomas F. Murray, and
Jane V. Aldrich
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BOOK REVIEWS
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5055-5055
| Annual Reports in Medicinal Chemistry. Volume 35 Editor-in-Chief, Annette Doherty. Academic Press, San Diego, CA. 2000. xi + 425 pp. 17.5 × 25.5 cm. ISBN 0-12-040535-0. $85.00.
Staff
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5055-5055
| Analytical Techniques in Combinatorial Chemistry Edited by Michael Swartz. Marcel Dekker, New York. 2000. xii + 301 pp. 15.5 × 23.5 cm. ISBN 0-8247-1939-5. $150.00.
Robert G. Gentles
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5055-5056
| Topological Indices and Related Descriptors in QSAR and QSPR Edited by James Devillers and Alexandru T. Balaban. Gordon and Breach Science Publishers, Amsterdam, The Netherlands. 1999. x + 811 pp. 15.5 × 23.5 cm. ISBN 90-5699-239-2. $198.00.
William J. Dunn III
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ADDITIONS AND CORRECTIONS
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5057-5057
| Synthesis and SAR of New 5-Phenyl-3-ureido-1,5-benzodiazepines as Cholecystokinin-B Receptor Antagonists.
Antonella Ursini,
Anna M. Capelli,
Robin A. E.
Carr,
Paolo Cassarà,
Mauro Corsi,
Ornella
Curcuruto,
Giovanni Curotto,
Michele Dal Cin,
Silvia Davalli,
Daniele Donati,
Aldo Feriani,
Harry Finch,
Gabriella Finizia,
Giovanni
Gaviraghi,
Marc Marien,
Giorgio Pentassuglia,
Stefano Polinelli,
Emiliangelo Ratti,
Aldo
Reggiani,
Giorgio Tarzia,
Giovanna Tedesco,
Maria E. Tranquillini,
David G. Trist, and
Frank T. M. Van Amsterdam:
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5057-5057
| Principles of Process Research and Chemical Development in the Pharmaceutical Industry. Edited by David J. Ager. Marcel Dekker, Inc., New York. 1999. x + 382 pp. 16 × 24 cm. ISBN 0-8247-1058-4. $165.00.
Pat N. Confalone:
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